Search results for "SCHIZOPHRENIA SPECTRUM DISORDERS"

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Childhood trauma and substance use underlying psychosis: a systematic review

2020

[EN] Background: Schizophrenia spectrum disorders (SSD) are mental diseases caused by a combination of genetic susceptibility and a number of environmental factors. Among these factors, the role of traumatic events suffered in childhood, as well as that of substance use, have been of particular research interest. Objectives: To conduct a systematic review to clarify whether there is an interaction between childhood trauma and substance use related to the diagnosis or symptoms of SSD. It was also the objective of this review to collate the associations that may exist between the three variables of the study (trauma, substance use and psychosis). Methods: We conducted a systematic search resu…

PsychosisSubstances useRC435-571Poison controlEsquizofreniaReview Article药物滥用Cannabis useSuicide preventionOccupational safety and healthChildhood traumaConsumo de cannabis思觉失调Injury preventionmedicinePsicosisPsychiatryWindow of opportunitybusiness.industryHuman factors and ergonomicsConsumo de sustanciasmedicine.diseasePsychosis• Schizophrenia is caused by a combination of genetic susceptibility and a number of environmental factors. Traumatic events suffered in childhood as well as substance use have been of particular interest.• Our results reveal a positive association between traumatic experiences in childhood and drug use and their interaction with schizophrenia spectrum disorders.• Detecting cases of childhood trauma as well as cases of trauma associated with substance use could be useful for the primary prevention of some psychiatric diseases such as psychosis.大麻使用精神分裂症SchizophreniaTrauma infantilSchizophreniabusiness童年创伤Clinical psychology
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Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway

2022

AbstractBackgroundThere is evidence that environmental and genetic risk factors for schizophrenia spectrum disorders are transdiagnostic and mediated in part through a generic pathway of affective dysregulation.MethodsWe analysed to what degree the impact of schizophrenia polygenic risk (PRS-SZ) and childhood adversity (CA) on psychosis outcomes was contingent on co-presence of affective dysregulation, defined as significant depressive symptoms, in (i) NEMESIS-2 (n = 6646), a representative general population sample, interviewed four times over nine years and (ii) EUGEI (n = 4068) a sample of patients with schizophrenia spectrum disorder, the siblings of these patients and controls.ResultsT…

RiskMultifactorial InheritancePsychosisHallucinationsAffective pathwayCLINICAL PSYCHOSISNEGATIVE SYMPTOMSDelusions03 medical and health sciences0302 clinical medicineMENTAL-HEALTH SURVEYchildhood adversityAffective dysregulationHumansMedicinegeneticspsychosisGenetic riskApplied Psychology1ST EPISODE PSYCHOSISGENERAL-POPULATIONbusiness.industryPSYCHIATRIC-DISORDERSSHORT-FORMAbsolute risk reductionNETWORK APPROACHIdeationmedicine.diseaseCHILDHOOD TRAUMA030227 psychiatryPsychiatry and Mental healthPsychotic DisordersSchizophreniaSchizophreniaSCHIZOPHRENIA SPECTRUM DISORDERSPolygenic risk scorebusinessenvironment030217 neurology & neurosurgerySchizophrenia spectrumClinical psychologyPsychological Medicine
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